Talks on peptide synthesisTwo slide shows. The first explains why amino acids cannot simply be heated together, introduces the Boc and Cbz groups on the amine and the methyl and benzyl esters on the acid, and shows how DCC activates the acid for coupling. The second follows the Merrifield synthesis on a polystyrene resin step by step, with its advantages and its limits.Draw the products and intermediates of a peptide synthesis, from protecting groups to DCC coupling, and follow two slide shows. The exercises need JavaScript, because every drawing is checked in your browser.

Why protect — heat two amino acids, and count what forms

Protecting groups — put them on, take them off

Coupling with DCC — activate the acid, then form the amide

Planning a synthesis — protect, couple, deprotect, in the right order

Builder — type a sequence, see the molecule

Cheatsheet — every group, how it goes on and comes off

Talks — two slide shows, mechanisms included

About — what the site is, and how to cite it

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