Peptide synthesis in solutionWhy two amino acids cannot simply be heated together, how Boc, Cbz, methyl and benzyl esters protect them, and how DCC activates the acid.Draw the products and intermediates of a peptide synthesis, from protecting groups to DCC coupling, and follow two slide shows. The exercises need JavaScript, because every drawing is checked in your browser.

Why protect — heat two amino acids, and count what forms

Protecting groups — put them on, take them off

Coupling with DCC — activate the acid, then form the amide

Planning a synthesis — protect, couple, deprotect, in the right order

Builder — type a sequence, see the molecule

Cheatsheet — every group, how it goes on and comes off

Talks — two slide shows, mechanisms included

About — what the site is, and how to cite it

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