Peptide synthesis on a solid supportThe Merrifield solid-phase peptide synthesis step by step: the polystyrene resin, the Boc cycle of deprotection and coupling, its advantages and its limits.Draw the products and intermediates of a peptide synthesis, from protecting groups to DCC coupling, and follow two slide shows. The exercises need JavaScript, because every drawing is checked in your browser.

Why protect — heat two amino acids, and count what forms

Protecting groups — put them on, take them off

Coupling with DCC — activate the acid, then form the amide

Planning a synthesis — protect, couple, deprotect, in the right order

Builder — type a sequence, see the molecule

Cheatsheet — every group, how it goes on and comes off

Talks — two slide shows, mechanisms included

About — what the site is, and how to cite it

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